Hawzah News Agency (Occupied Territoreies of Palestine) - Mohammed Nasser al-Rifi, 14, was seriously injured in an Israeli attack on his home in Al-Tuffah neighborhood, east of Gaza City, in 2014.
"He died of his wounds on Saturday at Al-Wafa hospital in Gaza," ministry spokesman Ashraf al-Qidra said in a statement.
The minor's father, brother and four relatives had died in the Israeli attack.
In July 2014, the Israeli army launched a 51-day offensive on the Gaza Strip on the pretext of halting rocket fire from the Palestinian territory.
A total of 2323 Palestinians were killed and around 11,000 others injured in the assault, according to figures released by the Palestinian Health Ministry.
The Gaza Strip has groaned under a crippling Israeli blockade since 2006 that has gutted the territory's economy and deprived its two million inhabitants of many staple commodities.